Use of this constitutes acceptance of our privacy policy All articles published by MDPI are made immediately available worldwide under an open access license. Pharmaceutics is an international peer-reviewed open access monthly journal published by MDPI. In this context, a series of newly synthesized surface-active fatty acid-protic ionic liquids (FA-PILs), based on tetramethylguanidinium cation and different natural hydrophobic fatty acid carboxylates, have been investigated with the aim of developing a pH-sensitive nanostructured drug delivery system for cutaneous administration in the skin cancer therapy. The statements, opinions and data contained in the journal, 1996-2022 MDPI (Basel, Switzerland) unless otherwise stated. However, epithelial barrier function can pose a challenge to their passive topical delivery. All submissions that pass pre-check are peer-reviewed. By combining drugs with different mechanisms of action, the limitations of each individual agent can be overcome, while increasing therapeutic benefit. progress in the field that systematically reviews the most exciting advances in scientific literature. Immunotherapies are approved to treat a variety of cancers. several techniques or approaches, or a comprehensive review paper with concise and precise updates on the latest Nanoparticles have become a powerful tool in oncology not only as carrier of the highly toxic chemotherapeutic drugs but also as imaging contrast agents that provide valuable information about the state of the disease and its progression. Furthermore, we also provide a regulatory overview from the United States Food and Drug Administration about MNs. Here, we designed a dual-targeting drug delivery system by conjugating paclitaxel (PTX)-loaded poly(ethylene glycol)-poly(lactic acid) nanoparticles (NPs) with a cyclic peptide (CNPs-PTX) with a special affinity with platelet-derived growth factor/platelet-derived growth factor receptor (PDGFR-) overexpressed on both CAFs and myeloma cells. In the fight against cancer, in recent years, researchers have put tremendous effort into evaluating the potential of drug carriers for this purpose. Further drug combinations should be evaluated in subsequent studies. Combination therapies constitute a powerful tool for cancer treatment. Combination therapies constitute a powerful tool for cancer treatment. Assessment of cytotoxic activities indicated that the optimized SMV-EMLs formula exhibited significantly lower half maximal inhibitory concentration (IC50) against MCF-7 cells. Several studies have also been directed at its use as anti-cancer drug during the last years, opening a window for its off-label use. The results of this testing will allow your doctor to make an informed decision about which drug is more likely to work for your type of cancer, based on the genetic mutations or other molecular characteristics of your tumor. published in the various research areas of the journal. The capability of FA-PILs to arrange in micelles when combined with each other and with the non-ionic surfactant d--Tocopherol polyethylene glycol succinate (vitamin E TPGS) as well as their ability to solubilize imiquimod, an immuno-stimulant drug used for the treatment of skin cancerous lesions, have been demonstrated. Original research papers, communications, review articles, and opinions are welcome. Some examples of hormone therapies include: Targeted therapies are part of a new approach known as personalized medicine or precision medicine. However, anodal iontophoresis resulted in significant amounts of co-encapsulated CDDP and DTX being deposited in the buccal mucosa; e.g., after current application for 10 min, the deposition of CDDP and DTX was 13.54 1.78 and 10.75 1.75 g/cm, Nanomaterials quickly evolve to produce safe and effective biomedical alternatives, mainly silver nanoparticles (AgNPs). The liposomes were elaborated by the reverse-phase method and characterized by physicochemical tests. To treat cancer, your doctor may recommend one type of oncology drug or a combination of drugs alongside surgery, radiation, or other types of treatment. For Once you are registered, click here to go to the submission form. The charged, deformable liposomesiontosomesdescribed here are able to overcome the buccal mucosal barrier via a combination of the electrical potential gradient imposed by iontophoresis and their shape-deforming characteristics. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. The magnetic/plasmonic nanoparticles were characterized using XRD, UV/Visible absorption, HR-TEM, and SQUID, exhibiting superparamagnetic behavior at room temperature. The standard treatment is cisplatin-based chemotherapy plus radiotherapy, but patient response is far from ideal. Subscribe to receive issue release notifications and newsletters from MDPI journals, You can make submissions to other journals. Please note that many of the page functionalities won't work as expected without javascript enabled. What Is The Link Between Lichen Sclerosus and Cancer? In summary, it is the first time that a dual-targeting strategy was utilized in the field of myeloma treatment through targeting both CAFs and myeloma cells simultaneously, which harbors a high potential of clinical translation for myeloma treatment. The aim is to provide a snapshot of some of the most exciting work Besides that, there is an emerging interest in their use as antineoplastic drugs as demonstrated by different studies showing their. Encapsulation in a (nano)carrier is a promising strategy to effectively improve the therapeutic effect of TMZ against GBM. They are non-invasive and are associated with significantly less or no pain at the site of administration to the skin. those of the individual authors and contributors and not of the publisher and the editor(s). Nanoparticles as carriers for these agents could be interesting by increasing the retention of chemotherapeutics within the peritoneal cavity. In this context, the aim of this Special Issue on New Formulations for Cancer Therapy is to gather papers addressing state-of-the-art trends and future directions in the development of clinically translatable carrier-based formulations for cancer treatment on topics ranging from rational design to relevant preclinical and/or clinical testing of efficacy, pharmacokinetics, and toxicity. Two chemotherapeutic agents with very different physicochemical properties, cisplatin (CDDP) and docetaxel (DTX), were co-encapsulated in cationic iontosomes comprising 1,2-dioleoyl-3-trimethylammonium-propane (DOTAP) and Lipoid-S75. Your doctor may decide to treat your cancer with a a single chemotherapy drug or a combination of chemotherapy drugs. This is mediated, at least in part, by enhanced pro-apoptotic activity and MMP modulation of SMV. 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Moreover, nanoparticles could be internalised by cancer cells and, The intraperitoneal administration of chemotherapeutics has emerged as a potential route in ovarian cancer treatment. Learn about the link between lichen sclerosus and vulvar cancer, including the possible causes, risk factors, symptoms to watch out for, and treatment. interesting to authors, or important in this field. Feature Papers represent the most advanced research with significant potential for high impact in the field. However, epithelial barrier function can pose a challenge to their passive topical delivery. Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). Besides that, there is an emerging interest in their use as antineoplastic drugs as demonstrated by different studies showing their cytotoxic activity against different cancer cells. To see if youre eligible for a particular targeted therapy, a doctor will first perform genetic or biomarker testing. In this context, a series of newly synthesized surface-active fatty acid-protic ionic liquids (FA-PILs). Further, the review also provides limitations, safety concerns, and latest updates about the clinical trials on MNs for the treatment of cancer. Feature The. The National Institutes of Health (NIH) maintains a large database of clinical trials at clinicaltrials.gov. In addition, the mitochondrial membrane potential (MMP) was significantly decreased. MDPI stays neutral with regard to jurisdictional claims in published maps and institutional affiliations. Research articles, review articles as well as short communications are invited. Last medically reviewed on September 19, 2021, Chemotherapy and immunotherapy are both used to treat cancer. Yet, the therapeutic efficacy of TMZ suffers from its inability to cross the BBB and very short half-life (~2 h), which requires high doses of this drug for a proper therapeutic effect. In the research for new drugs that enhance the activity of cisplatin, different therapeutic agents have been tested, among them the antiprogestin mifepristone. These may include: Hormone therapies can block your bodys ability to make hormones, and can interfere with how hormones act in your body. Is there a cure for cancer? This therapy will help to reduce relapse by eradicating cancerous cells in the margin of cervical tumors. A combination of disulfiram and 5-fluorouracil, which are both off-patent drugs and provide different modes of action, were evaluated. In addition, those products that have entered phase III clinical trials that have been active over the last five years are summarized in order to outline future research trends and possibilities that lie ahead to develop clinically translatable formulations for cancer treatment. Oncology drugs include a range of different types of medications, such as chemotherapy agents, targeted therapies, immunotherapies, and hormone therapies. You seem to have javascript disabled. Manuscripts can be submitted until the deadline. To determine the best treatment for you, your oncologist may perform molecular testing on your tumor among other imaging and blood tests. Oncology drugs are therapeutics used to treat cancer, a group of diseases caused by uncontrolled growth and division of abnormal cells. The successes (and failures) achieved with formulations that have been approved in Europe and/or by the FDA for the three major types of cancer therapy (peptide-based therapy, chemotherapy, and radiotherapy) are reviewed herein, covering the period from the approval of the first prolonged-release system for hormonal therapy to the appearance of the first biodegradable microspheres intended for chemoembolization in 2020. They are non-invasive and are associated with significantly less or no pain at the site of administration to the skin. Chemotherapy, for example, can attack some of the normal cells in your body especially blood cells, skin, hair, and the cells lining the intestine and mouth. Breast cancers may be fed by estrogen or progesterone, while prostate cancers often depend on the hormone androgen. The statements, opinions and data contained in the journals are solely The in vitro transport study using porcine mucosa indicated that iontosomes did not enter the mucosa without an external driving force. You are accessing a machine-readable page. This work reported the full characterization of a highly biocompatible protein-coated AgNPs formulation and their selective antitumor and amoebicidal activity. permission is required to reuse all or part of the article published by MDPI, including figures and tables. Can Immunotherapy Be Used for Metastatic Breast Cancer? In order to be human-readable, please install an RSS reader. Third, the combination of endostatin transfection and doxorubicin-nanoparticle loading was carried out with the decidua mesenchymal stromal cells. The nanosized nature of the carriers endows them with a specific surface area and inner space, increasing the stability of loaded drugs and prolonging their circulation time. Glioblastoma (GBM) is a lethal brain cancer with a very difficult therapeutic approach and ultimately frustrating results. The emulsomes were prepared using a modified thin-film hydration technique. Currently, therapeutic success is mainly limited by the high degree of genetic and phenotypic heterogeneity, the blood brain barrier (BBB), as well as increased drug resistance. These problems could possibly be addressed by the use of liposome nanoparticles to encapsulate drugs and deliver them to the target. This type of The magnetic/plasmonic nanoparticles were characterized using XRD, UV/Visible absorption, HR-TEM, and SQUID, exhibiting superparamagnetic behavior at room temperature. Learn about promising cancer treatments, from immunotherapy to, Angiogenesis inhibitors are a type of targeted cancer therapy. Healthline Media does not provide medical advice, diagnosis, or treatment. This may include certain types of breast cancer and prostate cancer. A task force says there's not enough evidence to support a recommendation on taking vitamins to reduce the risk of heart disease and cancer. Learn about immunotherapy for metastatic breast cancer, the four types, and. Cancer-associated fibroblasts (CAFs) and myeloma cells could mutually drive myeloma progression, indicating that drug delivery to kill both CAFs and myeloma cells simultaneously could achieve better therapeutic benefits than to kill each cell type alone. Nanogels constructed by chemical crosslinking or physical self-assembly exhibit the ability to encapsulate hydrophilic or hydrophobic therapeutics, including but not limited to small-molecule compounds and proteins, DNA/RNA sequences, and even ultrasmall nanoparticles, within their 3D polymer network. This study was performed to develop an adjuvant therapy in the form of a self-administered vaginal tablet regimen for the localized delivery of chemotherapeutic drugs. Curing Cancer: Newer Treatments to Keep an Eye On, Understanding the Connection Between Anemia and Cancer, Task Force Says Not Enough Evidence on Vitamins as a Way to Reduce Cancer, Heart Disease Risks, Liquid Biopsies Take Center Stage at the 2022 American Society of Clinical Oncologists Annual Meeting, Weight-Loss Surgery Slashes Cancer Risk and Mortality, New Study Finds. Febuxostat (FBX) is a drug able to inhibit xanthine oxidase and reduce uric acid production commonly used for the treatment of hyperuricemia in subjects suffering from gout. Editors select a small number of articles recently published in the journal that they believe will be particularly There are also different types of drugs available to help treat the side effects from oncology drugs. Cancer cells grow and divide more rapidly than other cells. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Subscribe FREE to eNewsletters, Magazines, Twitter or Linkedin: As new modalities are being developed for cancer therapies, formulation and process development considerations are becoming increasingly complex. The polymerpolymer interaction between the layers was able to reduce the loss of formulation due to chitosan. Submitted papers should be well formatted and use good English. In the research for. Glioblastoma (GBM) is a lethal brain cancer with a very difficult therapeutic approach and ultimately frustrating results. Noticeably, in the case of chemotherapeutic agents, drug encapsulation within carriers greatly contributes to reducing their frequent non-specific side effects that often lead to treatment discontinuation. Examples include: Oncology drugs have many benefits. Over the past few decades, the field of cancer therapy has seen a significant change in the way in which formulations are designed and developed, resulting in more efficient products that allow us to ultimately achieve improved drug bioavailability, efficacy, and safety. Additionally, several MN-based products are undergoing clinical trials to evaluate its safety, efficacy, and tolerability. Find support for a specific problem in the support section of our website. The intraperitoneal administration of chemotherapeutics has emerged as a potential route in ovarian cancer treatment. The aim of this review is not to present a comprehensive revision of the different theranostic mesoporous silica nanoparticles (MSN) which have been published in the recent years but just to describe a few selected examples to offer a panoramic view to the reader about the suitability and effectiveness of these nanocarriers in the oncology field. The targeted local delivery of anticancer therapeutics offers an alternative to systemic chemotherapy for oral cancers not amenable to surgical excision. A doctor may recommend that you treat your cancer with one or more of the following types of oncology drugs: Chemotherapy drugs are chemical agents that work by destroying fast-growing cells in the body. The staining of cells with Annex V revealed an increase in early and late apoptosis, in line with the increased cellular content of caspase-3 and Bax. The standard treatment is cisplatin-based chemotherapy plus radiotherapy, but patient response is far from ideal. Yes, you can have a say in your cancer treatment, including making the decision to delay treatment or not have treatment at all. Cytotoxicity tests showed that CNPs-PTX was more toxic to both CAFs and myeloma cells compared with its counterpart PTX-loaded conventional NPs (NPs-PTX). This special issue belongs to the section "Physical Pharmacy and Formulation". The results presented here show great potential for the development of combination therapies based on genetically-engineered cells that can simultaneously act as cellular vehicles for drug-loaded nanoparticles. Not quite, but new treatments could change that. The in vivo anti-tumor experiments confirmed that the anti-myeloma efficacy of CNPs-PTX was significantly stronger than that of NPs-PTX and free drugs. Here's what to know about the link. The cell cycle analysis showed a significant inhibition of the HCT 116 cells proliferation following FBX-EMLs treatment compared to all the other conditions, with a higher number of cells accumulating on G2/M and pre-G1 phases, paralleled by a significant reduction of cells in G0/G1 and S phases. Nanoparticle internalisation in SKOV-3 epithelial ovarian cancer cells mainly occurred between 2 and 4 h of incubation. Anemia and cancer often occur together. The aim of this work was to develop polymer nanoparticles as CBD carriers capable of being internalised by ovarian cancer cells. Febuxostat (FBX) is a drug able to inhibit xanthine oxidase and reduce uric acid production commonly used for the treatment of hyperuricemia in subjects suffering from gout. Cell cycle analysis indicated the accumulation of cells in the G2-M phase as well as increased cell fraction in the pre-G1 phase, suggesting an enhancement of anti-apoptotic activity of SMV. The Feature Paper can be either an original research article, a substantial novel research study that often involves Hormone therapy is used to treat cancers that rely on hormones to grow. Nanogels constructed by chemical crosslinking or physical self-assembly exhibit the ability to encapsulate hydrophilic or hydrophobic therapeutics, including but not limited to small-molecule compounds and proteins, DNA/RNA sequences, and even ultrasmall nanoparticles. In conclusion, the new formulation of FBX into EMLs improved all the parameters related to the anti-proliferative activity and the toxic potential of the drug towards colorectal cancer cells. Moreover, the biomembrane-camouflaged nanogels exhibit additional intelligent targeted delivery features. The encapsulation efficiency was high, with values above 95%. The vaginal tablet is a very common formulation that is easy to manufacture, easy to place in the vagina, and has a low cost of manufacture, making them ideal for use in developing countries. Cancer treatment is constantly evolving and progressing. There are over 100 types of cancer, according to the National Cancer Institute (NCI). You can also seek a second opinion from another qualified doctor. Cervical cancer is usually diagnosed in the later stages despite many campaigns for early detection and continues to be a major public health problem. Please let us know what you think of our products and services. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website. Common side effects of chemotherapy include: Targeted therapies and immunotherapies often have fewer side effects compared to chemotherapy since they only attack cancer cells while sparing healthy cells from harm, but they can still cause side effects. Cellular uptake experiments revealed that the cyclic peptide modification on CNPs could significantly enhance CNPs uptake by both CAFs and myeloma cells compared with unmodified NPs. While the bilayer tablet had satisfactory performance in the physicochemical tests, in vitro cell culture with Ca-Ski also showed a synergistic effect using a combination of drugs at a low dose. The tablets developed were evaluated for weight variation, thickness, hardness, friability, swelling index, differential scanning calorimetry (DSC), particle morphology, in vitro drug release, and cytotoxicity on Ca-Ski cells. Nevertheless, the efficacy of cisplatin is limited by its low specificity for tumor tissue, which causes severe side effects. Microneedles (MNs) are tiny needle like structures used in drug delivery through layers of the skin. The search for new formulations for cancer therapy to achieve improved bioavailability, efficacy, and safety constitutes the holy grail of anticancer drug research. You can obtain detailed information about the use of cookies on our website by clicking on "More information. The optimized formula was also able to significantly increase the percentage of cell population in both early and late stages of apoptosis, characterized by a higher intracellular caspase-3 concentration, as well as percentage of necrotic cells. A special issue of Pharmaceutics (ISSN 1999-4923). Here, we designed a dual-targeting drug delivery system. To improve therapeutic outcomes and increase the precision of therapy, nanogels can be modified by specific ligands to achieve active targeting and enhance the drug accumulation in disease sites. Please visit the Instructions for Authors page before submitting a manuscript. Temozolomide (TMZ), a monofunctional alkylating agent, is the first line chemotherapeutic drug for GBM treatment. These drug-loaded liposomes significantly decreased cell viability in vitro and tumor size in vivo, without generating systemic toxicity in the animals. Cancer cells sometimes have strategic ways of hiding from your immune system, but immunotherapies work by blocking these mechanisms. However, the formulation only had 24-h dose release before degradation. The enhanced permeation and retention effect for loaded nanocarriers in tumors allow substantial improvement of selectivity and safety of anticancer nanomedicines. All rights reserved. Help us to further improve by taking part in this short 5 minute survey, Special Issues, Collections and Topics in MDPI journals, New Formulations for Cancer Therapy Volume II, Magnetoliposomes Based on Magnetic/Plasmonic Nanoparticles Loaded with Tricyclic Lactones for Combined Cancer Therapy, https://doi.org/10.3390/pharmaceutics13111905, Nanoparticles Dual Targeting Both Myeloma Cells and Cancer-Associated Fibroblasts Simultaneously to Improve Multiple Myeloma Treatment, https://doi.org/10.3390/pharmaceutics13020274, Endostatin Genetically Engineered Placental Mesenchymal Stromal Cells Carrying Doxorubicin-Loaded Mesoporous Silica Nanoparticles for Combined Chemo- and Antiangiogenic Therapy, https://doi.org/10.3390/pharmaceutics13020244, Iontosomes: Electroresponsive Liposomes for Topical Iontophoretic Delivery of Chemotherapeutics to the Buccal Mucosa, https://doi.org/10.3390/pharmaceutics13010088, New Protein-Coated Silver Nanoparticles: Characterization, Antitumor and Amoebicidal Activity, Antiproliferative Selectivity, Genotoxicity, and Biocompatibility Evaluation, https://doi.org/10.3390/pharmaceutics13010065, A Bilayer Vaginal Tablet for the Localized Delivery of Disulfiram and 5-Fluorouracil to the Cervix, https://doi.org/10.3390/pharmaceutics12121185, pH-Responsive Nanostructures Based on Surface Active Fatty Acid-Protic Ionic Liquids for Imiquimod Delivery in Skin Cancer Topical Therapy, https://doi.org/10.3390/pharmaceutics12111078, The Encapsulation of Febuxostat into Emulsomes Strongly Enhances the Cytotoxic Potential of the Drug on HCT 116 Colon Cancer Cells, https://doi.org/10.3390/pharmaceutics12100956, Liposomes Co-Encapsulating Cisplatin/Mifepristone Improve the Effect on Cervical Cancer: In Vitro and In Vivo Assessment, https://doi.org/10.3390/pharmaceutics12090897, Protective Role of IRBIT on Sodium Bicarbonate Cotransporter-n1 for Migratory Cancer Cells, https://doi.org/10.3390/pharmaceutics12090816, The Enhanced Cytotoxic and Pro-Apoptotic Effects of Optimized Simvastatin-Loaded Emulsomes on MCF-7 Breast Cancer Cells, https://doi.org/10.3390/pharmaceutics12070597, PLGA Nanoparticles for the Intraperitoneal Administration of CBD in the Treatment of Ovarian Cancer: In Vitro and In Ovo Assessment, https://doi.org/10.3390/pharmaceutics12050439, Liposomal-Based Formulations: A Path from Basic Research to Temozolomide Delivery Inside Glioblastoma Tissue, https://doi.org/10.3390/pharmaceutics14020308, Microneedles Drug Delivery Systems for Treatment of Cancer: A Recent Update, https://doi.org/10.3390/pharmaceutics12111101, Timeline of Translational Formulation Technologies for Cancer Therapy: Successes, Failures, and Lessons Learned Therefrom, https://doi.org/10.3390/pharmaceutics12111028, Mesoporous Silica Nanoparticles as Theranostic Antitumoral Nanomedicines, https://doi.org/10.3390/pharmaceutics12100957, Nanogel: A Versatile Nano-Delivery System for Biomedical Applications, https://doi.org/10.3390/pharmaceutics12030290.
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